The difference between Fruitless and Vain
When used as adjectives, fruitless means bearing no fruit, whereas vain means overly proud of oneself, especially concerning appearance.
check bellow for the other definitions of Fruitless and Vain
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Fruitless as an adjective:
Bearing no fruit; barren.
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Fruitless as an adjective (figuratively):
Unproductive, useless.
Examples:
"The unskilled man’s attempt at fixing his car engine was fruitless."
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Fruitless as an adjective (figuratively, archaic):
Of a person: unable to have children; barren, infertile.
Examples:
"The fruitless woman desperately wanted to have children."
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Fruitless as an adjective (rare):
Of a diet, etc.: without fruit.
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Vain as an adjective:
Overly proud of oneself, especially concerning appearance; having a high opinion of one's own accomplishments with slight reason.
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Vain as an adjective:
Having no real substance, value, or importance; empty; void; worthless; unsatisfying.
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Vain as an adjective:
Effecting no purpose; pointless, futile.
Examples:
"'vain toil;  a vain attempt"
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Vain as an adjective:
Showy; ostentatious.