The difference between Children and Offspring

When used as nouns, children means ., whereas offspring means a person's daughter(s) and/or son(s).

check bellow for the other definitions of Children and Offspring

Offspring as a noun:

A person's daughter(s) and/or son(s); a person's children.
Offspring as a noun:

All of a person's descendants, including further generations.
Offspring as a noun:

An animal or plant's progeny or young.
Offspring as a noun (figuratively):

Anything produced; the result of an entity's efforts.

Examples:

"Artists often treasure their works as their immortal offspring."
Offspring as a noun (computing):

A process launched by another process.