The difference between S and Significant other
S is also abbreviation with the meaning: abbreviation for the scruple.
Significant other is also noun with the meaning: one's romantic partner, regardless of marital status or gender.
check bellow for the other definitions of S and Significant other
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Significant other as a noun:
One's romantic partner, regardless of marital status or gender.
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Significant other as a noun:
A person with whom one has an important bond of some kind.