The difference between Dope and Substance

Dope as a noun (uncountable):

Any viscous liquid or paste, such as a lubricant, used in preparing a surface.

Dope as a noun (uncountable):

An absorbent material used to hold a liquid.

Dope as a noun (uncountable, aeronautics):

Any varnish used to coat a part, such as an airplane wing or a hot-air balloon in order to waterproof, strengthen, etc.

Dope as a noun (uncountable, slang):

Any illicit or narcotic drug that produces euphoria or satisfies an addiction; particularly heroin.

Dope as a noun (uncountable, slang):

Information, usually from an inside source, originally in horse racing and other sports.

Dope as a noun (uncountable, fireams):

Ballistic data on previously fired rounds, used to calculate the required hold over a target.

Dope as a noun (countable, slang):

A stupid person.

Dope as a noun (US, Ohio):

dessert topping

Dope as a verb (transitive, slang):

To affect with drugs.

Dope as a verb (transitive):

To treat with dope (lubricant, etc.).

Dope as a verb (transitive, electronics):

To add a dopant such as arsenic to (a pure semiconductor such as silicon).

Dope as a verb (slang):

To use drugs; especially, to use prohibited performance-enhancing drugs in sporting competitions.

Dope as a verb (slang, transitive, dated):

To judge or guess; to predict the result of.

Dope as an adjective (slang):

Amazing.

Substance as a noun:

Physical matter; material.

Substance as a noun:

The essential part of anything; the most vital part.

Substance as a noun:

Substantiality; solidity; firmness.

Substance as a noun:

Material possessions; estate; property; resources.

Substance as a noun:

A form of matter that has constant chemical composition and characteristic properties.

Substance as a noun:

Drugs

Substance as a noun (theology):

Hypostasis.

Substance as a verb (rare, transitive):

To give substance to; to make real or substantial.