The difference between Come what may and In any case
When used as adverbs, come what may means in spite of anything that might happen, whereas in any case means at any rate, anyhow.
check bellow for the other definitions of Come what may and In any case
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Come what may as an adverb (idiomatic):
In spite of anything that might happen; whatever may occur.
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In any case as an adverb:
At any rate, anyhow.