The difference between As a whole and In general
As a whole is also phrase with the meaning: considered all together.
In general is also adverb with the meaning: in the general case.
check bellow for the other definitions of As a whole and In general
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In general as an adverb:
In the general case; without further assumption; without qualification; in all respects.
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In general as an adverb:
As a rule; usually.